Autonomous DNA nanostructures instructed by hierarchically concatenated chemical reaction networks
- Sep 27, 2021
- 1 min read
Read the full article here: Nat Commun 12, 5132 (2021)
by J. Deng and A. Walther
Concatenation and communication between chemically distinct chemical reaction networks (CRNs) is an essential principle in biology for controlling dynamics of hierarchical structures. Here, to provide a model system for such biological systems, we demonstrate autonomous lifecycles of DNA nanotubes (DNTs) by two concatenated CRNs using different thermodynamic principles: (1) ATP-powered ligation/restriction of DNA components and (2) input strand-mediated DNA strand displacement (DSD) using energy gains provided in DNA toeholds. This allows to achieve hierarchical non-equilibrium systems by concurrent ATP-powered ligation-induced DSD for activating DNT self-assembly and restriction-induced backward DSD reactions for triggering DNT degradation. We introduce indirect and direct activation of DNT self-assemblies, and orthogonal molecular recognition allows ATP-fueled self-sorting of transient multicomponent DNTs. Coupling ATP dissipation to DNA nanostructures via programmable DSD is a generic concept which should be widely applicable to organize other DNA nanostructures, and enable the design of automatons and life-like systems of higher structural complexity.
This was a very enjoyable read. I appreciate the time and effort that went into creating such helpful content. I also use a pinterest video downloader whenever I find videos worth keeping for later.
Paglu Game download was quick and easy. The game offers great entertainment with interesting features and levels. I’ve been playing daily and it keeps getting more engaging every time.
DG Club login was quick and easy. The game offers great entertainment with interesting features and levels. I’ve been playing daily and it keeps getting more engaging every time.
V3 Game login was quick and easy. The game offers great entertainment with interesting features and levels. I’ve been playing daily and it keeps getting more engaging every time.
I enjoyed reading this post because the information is shared in a simple and practical way. The article feels genuine and informative. instagram reels download is a topic many people are interested in, and this content adds value to the discussion.